%0 Journal Article
%J BMC medical research methodology
%D 2005
%T Use of re-randomized data in meta-analysis.
%A Hozo, Iztok
%A Djulbegovic, Benjamin
%A Clark, Otavio
%A Lyman, Gary H
%K Colony-Stimulating Factors
%K Data Interpretation, Statistical
%K Humans
%K Meta-Analysis as Topic
%K Models, Statistical
%K NEUTROPENIA
%K Odds Ratio
%K Outcome Assessment (Health Care)
%K Patient Selection
%K Randomized Controlled Trials as Topic
%K RECURRENCE
%K Seizures, Febrile
%K Selection Bias
%P 17
%V 5
%X Outcomes collected in randomized clinical trials are observations of random variables that should be independent and identically distributed. However, in some trials, the patients are randomized more than once thus violating both of these assumptions. The probability of an event is not always the same when a patient is re-randomized; there is probably a non-zero covariance coming from observations on the same patient. This is of particular importance to the meta-analysts.
%8 2005