Center-Authored Papers

Filters: Author is Takeuchi, Ryo  [Clear All Filters]
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2009
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
McConnell Smith A, Takeuchi R, Pellenz S, Davis L, Maizels N, Monnat RJ, Stoddard BL.  2009.  Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease.. Proceedings of the National Academy of Sciences of the United States of America. 106(13):5099-104. Abstract
Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.  2009.  Exploitation of binding energy for catalysis and design.. Nature. 461(7268):1300-4. Abstract
2011
Takeuchi R, Lambert AR, Mak AN-S, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL.  2011.  Tapping natural reservoirs of homing endonucleases for targeted gene modification.. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13077-82. Abstract
2012
Khare SD, Kipnis Y, Greisen PJ, Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H et al..  2012.  Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.. Nature chemical biology. 8(3):294-300. Abstract
2013
Chan Y-S, Takeuchi R, Jarjour J, Huen DS, Stoddard BL, Russell S.  2013.  The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive.. PloS one. 8(9):e74254. Abstract
2014
Takeuchi R, Choi M, Stoddard BL.  2014.  Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization.. Proceedings of the National Academy of Sciences of the United States of America. 111(11):4061-6. Abstract
336
Khare SD, Kipnis Y, Greisen PJ, Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H et al..  2012.  Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.. Nature chemical biology. 8(3):294-300. Abstract
Amino Acid Sequence
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
Amino Acid Substitution
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
Amino Acids
Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville JE, Gregg CJ, Stoddard BL, Church GM.  2015.  Biocontainment of genetically modified organisms by synthetic protein design.. Nature. 518(7537):55-60. Abstract
April 2014
Takeuchi R, Choi M, Stoddard BL.  2014.  Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization.. Proceedings of the National Academy of Sciences of the United States of America. 111(11):4061-6. Abstract
Base Sequence
McConnell Smith A, Takeuchi R, Pellenz S, Davis L, Maizels N, Monnat RJ, Stoddard BL.  2009.  Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease.. Proceedings of the National Academy of Sciences of the United States of America. 106(13):5099-104. Abstract
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
Basic Sciences Division
McConnell Smith A, Takeuchi R, Pellenz S, Davis L, Maizels N, Monnat RJ, Stoddard BL.  2009.  Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease.. Proceedings of the National Academy of Sciences of the United States of America. 106(13):5099-104. Abstract
Takeuchi R, Lambert AR, Mak AN-S, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL.  2011.  Tapping natural reservoirs of homing endonucleases for targeted gene modification.. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13077-82. Abstract
Khare SD, Kipnis Y, Greisen PJ, Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I, Leader H et al..  2012.  Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.. Nature chemical biology. 8(3):294-300. Abstract
Takeuchi R, Choi M, Stoddard BL.  2014.  Redesign of extensive protein-DNA interfaces of meganucleases using iterative cycles of in vitro compartmentalization.. Proceedings of the National Academy of Sciences of the United States of America. 111(11):4061-6. Abstract
Chan Y-S, Takeuchi R, Jarjour J, Huen DS, Stoddard BL, Russell S.  2013.  The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive.. PloS one. 8(9):e74254. Abstract
Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.  2009.  Exploitation of binding energy for catalysis and design.. Nature. 461(7268):1300-4. Abstract
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
Binding Sites
Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.  2009.  Exploitation of binding energy for catalysis and design.. Nature. 461(7268):1300-4. Abstract
Biocatalysis
Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.  2009.  Exploitation of binding energy for catalysis and design.. Nature. 461(7268):1300-4. Abstract
Biological Evolution
Mandell DJ, Lajoie MJ, Mee MT, Takeuchi R, Kuznetsov G, Norville JE, Gregg CJ, Stoddard BL, Church GM.  2015.  Biocontainment of genetically modified organisms by synthetic protein design.. Nature. 518(7537):55-60. Abstract
CATALYTIC DOMAIN
McConnell Smith A, Takeuchi R, Pellenz S, Davis L, Maizels N, Monnat RJ, Stoddard BL.  2009.  Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease.. Proceedings of the National Academy of Sciences of the United States of America. 106(13):5099-104. Abstract