Center-Authored Papers

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Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D et al..  2014.  megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.. Nucleic acids research. 42(4):2591-601. Abstract
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Taylor GK, Petrucci LH, Lambert AR, Baxter SK, Jarjour J, Stoddard BL.  2012.  LAHEDES: the LAGLIDADG homing endonuclease database and engineering server.. Nucleic acids research. 40(W1):W110-W116. Abstract
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Lambert AR, Hallinan JP, Shen BW, Chik JK, Bolduc JM, Kulshina N, Robins LI, Kaiser BK, Jarjour J, Havens K et al..  2016.  Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.. Structure (London, England : 1993). Abstract
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Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM.  2009.  High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display.. Nucleic acids research. 37(20):6871-80. Abstract
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Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.  2009.  Exploitation of binding energy for catalysis and design.. Nature. 461(7268):1300-4. Abstract
Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.  2012.  Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.. Nucleic acids research. 40(11):4954-4964. Abstract
Baxter S, Lambert AR, Kuhar R, Jarjour J, Kulshina N, Parmeggiani F, Danaher P, Gano J, Baker D, Stoddard BL et al..  2012.  Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases.. Nucleic acids research. Abstract
Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A et al..  2016.  Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.. Molecular therapy. Nucleic acids. 5(8):e352. Abstract
Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J et al..  2015.  Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.. Science translational medicine. 7(307):307ra156. Abstract
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Chan Y-S, Takeuchi R, Jarjour J, Huen DS, Stoddard BL, Russell S.  2013.  The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive.. PloS one. 8(9):e74254. Abstract
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Werther R, Hallinan JP, Lambert AR, Havens K, Pogson M, Jarjour J, Galizi R, Windbichler N, Crisanti A, Nolan T et al..  2017.  Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.. Nucleic acids research. Abstract