Center-Authored Papers

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Shen BW, Xu D, Chan S-H, Zheng Y, Zhu Z, Xu S-Y, Stoddard BL.  2011.  Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI.. Nucleic acids research. 39(18):8223-36. Abstract
Siegel JB, Smith AL, Poust S, Wargacki AJ, Bar-Even A, Louw C, Shen BW, Eiben CB, Tran HM, Noor E et al..  2015.  Computational protein design enables a novel one-carbon assimilation pathway.. Proceedings of the National Academy of Sciences of the United States of America. 112(12):3704-9. Abstract
Berger S, Procko E, Margineantu D, Lee EF, Shen BW, Zelter A, Silva D-A, Chawla K, Herold MJ, Garnier J-M et al..  2016.  Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.. eLife. 5 Abstract
Procko E, Berguig GY, Shen BW, Song Y, Frayo S, Convertine AJ, Margineantu D, Booth G, Correia BE, Cheng Y et al..  2014.  A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells.. Cell. 157(7):1644-56. Abstract
Park K, Shen BW, Parmeggiani F, Huang P-S, Stoddard BL, Baker D.  2015.  Control of repeat-protein curvature by computational protein design.. Nature structural & molecular biology. 22(2):167-74. Abstract
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Shen BW, Heiter DF, Lunnen KD, Wilson GG, Stoddard BL.  2017.  DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target.. Nucleic acids research. 45(3):1516-1528. Abstract
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Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.  2012.  Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.. Nucleic acids research. 40(11):4954-4964. Abstract
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Eiben CB, Siegel JB, Bale JB, Cooper S, Khatib F, Shen BW, Players F, Stoddard BL, Popovic Z, Baker D.  2012.  Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.. Nature biotechnology. 30(2):190-2. Abstract
Lambert AR, Hallinan JP, Shen BW, Chik JK, Bolduc JM, Kulshina N, Robins LI, Kaiser BK, Jarjour J, Havens K et al..  2016.  Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.. Structure (London, England : 1993). Abstract
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Shen BW, Lambert A, Walker BC, Stoddard BL, Kaiser BK.  2016.  The structural basis of asymmetry in DNA binding and cleavage as exhibited by the I-SmaMI LAGLIDADG meganuclease.. Journal of molecular biology. 428(1):206-220. Abstract
Kaiser BK, Clifton MC, Shen BW, Stoddard BL.  2009.  The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease.. Structure (London, England : 1993). 17(10):1368-76. Abstract
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Shen BW, Spiegel PC, Chang C-H, Huh J-W, Lee J-S, Kim J, Kim Y-H, Stoddard BL.  2008.  The tertiary structure and domain organization of coagulation factor VIII.. Blood. 111(3):1240-7. Abstract
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Shen BW, Heiter DF, Chan S-H, Wang H, Xu S-Y, Morgan RD, Wilson GG, Stoddard BL.  2010.  Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI.. Structure (London, England : 1993). 18(6):734-43. Abstract