Center-Authored Papers

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Journal Article
Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM et al..  2016.  Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death.. PLoS pathogens. 12(10):e1005910. Abstract
Massa V, Savery D, Ybot-Gonzalez P, Ferraro E, Rongvaux A, Cecconi F, Flavell R, Greene NDE, Copp AJ.  2009.  Apoptosis is not required for mammalian neural tube closure.. Proceedings of the National Academy of Sciences of the United States of America. 106(20):8233-8. Abstract
Rongvaux A, Jackson R, Harman CCD, Li T, West PA, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan C-Y et al..  2014.  Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.. Cell. 159(7):1563-77. Abstract
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H et al..  2015.  Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.. Nature. 517(7534):381-5. Abstract
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM et al..  2011.  Control of TH17 cells occurs in the small intestine.. Nature. 475(7357):514-8. Abstract
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka KA et al..  2014.  Development and function of human innate immune cells in a humanized mouse model.. Nature biotechnology. 32(4):364-72. Abstract
Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA.  2011.  Efficient differentiation and function of human macrophages in humanized CSF-1 mice.. Blood. 118(11):3119-28. Abstract
Cardona M, López JA, Serafín A, Rongvaux A, Inserte J, García-Dorado D, Flavell R, Llovera M, Cañas X, Vázquez J et al..  2015.  Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart.. PloS one. 10(6):e0131411. Abstract
Henao-Mejia J, Williams A, Rongvaux A, Stein J, Hughes C, Flavell RA.  2016.  Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System.. Cold Spring Harbor protocols. 2016(2):pdb.prot090704. Abstract
Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E et al..  2016.  Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.. Nature immunology. 17(11):1282-1290. Abstract
Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.  2013.  Human hemato-lymphoid system mice: current use and future potential for medicine.. Annual review of immunology. 31:635-74. Abstract
Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG et al..  2011.  Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung.. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2390-5. Abstract
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S et al..  2011.  Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2378-83. Abstract
Theocharides APA, Rongvaux A, Fritsch K, Flavell RA, Manz MG.  2016.  Humanized hemato-lymphoid system mice.. Haematologica. 101(1):5-19. Abstract
Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP et al..  2009.  Humanized mice for modeling human infectious disease: challenges, progress, and outlook.. Cell host & microbe. 6(1):5-9. Abstract
Willinger T, Rongvaux A, Strowig T, Manz MG, Flavell RA.  2011.  Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement.. Trends in immunology. 32(7):321-7. Abstract
Andris F, Denanglaire S, Baus E, Rongvaux A, Steuve J, Flavell RA, Leo O.  2011.  Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.. Journal of immunology (Baltimore, Md. : 1950). 186(4):2245-53. Abstract
Radtke S, Chan Y-Y, Sippel TR, Kiem H-P, Rongvaux A.  2019.  MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.. Experimental hematology. 70:31-41.e1. Abstract
Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, Galán JE.  2010.  A mouse model for the human pathogen Salmonella typhi.. Cell host & microbe. 8(4):369-76. Abstract
Rongvaux A, Galli M, Denanglaire S, Van Gool F, Drèze PL, Szpirer C, Bureau F, Andris F, Leo O.  2008.  Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress.. Journal of immunology (Baltimore, Md. : 1950). 181(7):4685-95. Abstract
Gallí M, Van Gool F, Rongvaux A, Andris F, Leo O.  2010.  The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer.. Cancer research. 70(1):8-11. Abstract
Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG et al..  2012.  NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.. Nature. 484(7395):510-3. Abstract
Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G et al..  2015.  Nlrp6 regulates intestinal antiviral innate immunity.. Science (New York, N.Y.). 350(6262):826-30. Abstract
Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A, Leo O.  2014.  PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.. The Journal of biological chemistry. 289(38):26642-57. Abstract
Ye J, Llorian M, Cardona M, Rongvaux A, Moubarak RS, Comella JX, Bassel-Duby R, Flavell RA, Olson EN, Smith CWJ et al..  2013.  A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.. Journal of cell science. 126(Pt 7):1682-91. Abstract