Center-Authored Papers

Filters: Author is Scharenberg, Andrew M  [Clear All Filters]
2016
Gwiazda KS, Grier AE, Sahni J, Burleigh SM, Martin U, Yang JG, Popp NA, Krutein MC, Khan IF, Jacoby K et al..  2016.  High efficiency CRISPR/Cas9-mediated gene editing in primary human T-cells using mutant adenoviral E4orf6/E1b55k "helper" proteins.. Molecular therapy : the journal of the American Society of Gene Therapy. Abstract
Lambert AR, Hallinan JP, Shen BW, Chik JK, Bolduc JM, Kulshina N, Robins LI, Kaiser BK, Jarjour J, Havens K et al..  2016.  Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.. Structure (London, England : 1993). Abstract
Sedlak RH, Liang S, Niyonzima N, De Silva Feelixge HS, Roychoudhury P, Greninger AL, Weber ND, Boissel S, Scharenberg AM, Cheng A et al..  2016.  Digital detection of endonuclease mediated gene disruption in the HIV provirus.. Scientific reports. 6:20064. Abstract
Grier AE, Burleigh S, Sahni J, Clough CA, Cardot V, Choe DC, Krutein MC, Rawlings DJ, Jensen MC, Scharenberg AM et al..  2016.  pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.. Molecular therapy. Nucleic acids. 5:e306. Abstract
2015
Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J et al..  2015.  Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.. Science translational medicine. 7(307):307ra156. Abstract
Osborn MJ, Webber BR, Knipping F, Lonetree C-L, Tennis N, DeFeo AP, McElroy AN, Starker CG, Lee C, Gabriel R et al..  2015.  Evaluation of TCR Gene Editing achieved by TALENs, CRISPR/Cas9 and megaTAL nucleases.. Molecular therapy : the journal of the American Society of Gene Therapy. Abstract
2014
Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ et al..  2014.  Intravenous injection of a foamy virus vector to correct canine SCID-X1.. Blood. 123(23):3578-84. Abstract
Aubert M, Boyle NM, Stone D, Stensland L, Huang M-L, Magaret AS, Galetto R, Rawlings DJ, Scharenberg AM, Jerome KR.  2014.  In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease.. Molecular therapy. Nucleic acids. 3:e146. Abstract
Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D et al..  2014.  megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.. Nucleic acids research. 42(4):2591-601. Abstract
2012
Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K et al..  2012.  Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.. Nature methods. 9(10):973-5. Abstract
Baxter S, Lambert AR, Kuhar R, Jarjour J, Kulshina N, Parmeggiani F, Danaher P, Gano J, Baker D, Stoddard BL et al..  2012.  Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases.. Nucleic acids research. Abstract
Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.  2012.  Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.. Nucleic acids research. 40(11):4954-4964. Abstract
Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem H-P.  2012.  Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.. Nucleic acids research. 40(2) Abstract
2011
Takeuchi R, Lambert AR, Mak AN-S, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL.  2011.  Tapping natural reservoirs of homing endonucleases for targeted gene modification.. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13077-82. Abstract
Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR.  2011.  Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.. PloS one. 6(2):e16825. Abstract
2010
Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders JE, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD et al..  2010.  Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.. The Journal of allergy and clinical immunology. 126(5):1000-5. Abstract
2009
Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.  2009.  Exploitation of binding energy for catalysis and design.. Nature. 461(7268):1300-4. Abstract
Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM.  2009.  High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display.. Nucleic acids research. 37(20):6871-80. Abstract
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract