Center-Authored Papers

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Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders JE, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD et al..  2010.  Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.. The Journal of allergy and clinical immunology. 126(5):1000-5. Abstract
2009
Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.  2009.  Exploitation of binding energy for catalysis and design.. Nature. 461(7268):1300-4. Abstract
Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM.  2009.  High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display.. Nucleic acids research. 37(20):6871-80. Abstract
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
2010
Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders JE, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD et al..  2010.  Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.. The Journal of allergy and clinical immunology. 126(5):1000-5. Abstract
2011
Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR.  2011.  Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.. PloS one. 6(2):e16825. Abstract
Takeuchi R, Lambert AR, Mak AN-S, Jacoby K, Dickson RJ, Gloor GB, Scharenberg AM, Edgell DR, Stoddard BL.  2011.  Tapping natural reservoirs of homing endonucleases for targeted gene modification.. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13077-82. Abstract
2012
Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K et al..  2012.  Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.. Nature methods. 9(10):973-5. Abstract
Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem H-P.  2012.  Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.. Nucleic acids research. 40(2) Abstract
Baxter S, Lambert AR, Kuhar R, Jarjour J, Kulshina N, Parmeggiani F, Danaher P, Gano J, Baker D, Stoddard BL et al..  2012.  Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases.. Nucleic acids research. Abstract
Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.  2012.  Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.. Nucleic acids research. 40(11):4954-4964. Abstract
2013
Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D et al..  2014.  megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.. Nucleic acids research. 42(4):2591-601. Abstract
2014
Aubert M, Boyle NM, Stone D, Stensland L, Huang M-L, Magaret AS, Galetto R, Rawlings DJ, Scharenberg AM, Jerome KR.  2014.  In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease.. Molecular therapy. Nucleic acids. 3:e146. Abstract
Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ et al..  2014.  Intravenous injection of a foamy virus vector to correct canine SCID-X1.. Blood. 123(23):3578-84. Abstract
Adolescent
Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders JE, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD et al..  2010.  Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.. The Journal of allergy and clinical immunology. 126(5):1000-5. Abstract
Amino Acid Sequence
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
Amino Acid Substitution
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
April 2014
Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ et al..  2014.  Intravenous injection of a foamy virus vector to correct canine SCID-X1.. Blood. 123(23):3578-84. Abstract
Base Sequence
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR.  2011.  Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.. PloS one. 6(2):e16825. Abstract
Basic Sciences Division
Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM.  2009.  High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display.. Nucleic acids research. 37(20):6871-80. Abstract
Takeuchi R, Certo M, Caprara MG, Scharenberg AM, Stoddard BL.  2009.  Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.. Nucleic acids research. 37(3):877-90. Abstract
Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.  2012.  Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.. Nucleic acids research. 40(11):4954-4964. Abstract
Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D et al..  2014.  megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.. Nucleic acids research. 42(4):2591-601. Abstract
Baxter S, Lambert AR, Kuhar R, Jarjour J, Kulshina N, Parmeggiani F, Danaher P, Gano J, Baker D, Stoddard BL et al..  2012.  Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases.. Nucleic acids research. Abstract