Center-Authored Papers

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Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D et al..  2014.  megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.. Nucleic acids research. 42(4):2591-601. Abstract
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Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A et al..  2016.  Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.. Molecular therapy. Nucleic acids. 5(8):e352. Abstract
Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J et al..  2015.  Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.. Science translational medicine. 7(307):307ra156. Abstract
Paul B, Ibarra GRS, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem H-P, Peterson CW.  2018.  Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase.. Molecular therapy. Methods & clinical development. 9:347-357. Abstract