Center-Authored Papers

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Journal Article
Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvári M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ et al..  2011.  Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.. Nature. 477(7365):482-5. Abstract
Nemecek ER, Guthrie KA, Sorror ML, Wood BL, Doney K, Hilger RA, Scott BL, Kovacsovics TJ, Maziarz RT, Woolfrey AE et al..  2011.  Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(3):341-50. Abstract
Wang J, Wegener JE, Huang T-W, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J et al..  2015.  Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.. Nature. 525(7570):552.
Mahajan SS, Scian M, Sripathy S, Posakony J, Lao U, Loe TK, Leko V, Thalhofer A, Schuler AD, Bedalov A et al..  2014.  Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors.. Journal of medicinal chemistry. 57(8):3283-94. Abstract
Leko V, Park GJ, Lao U, Simon JA, Bedalov A.  2013.  Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC(+/min) Mouse Model.. PloS one. 8(6):e66283. Abstract
Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A.  2011.  Genetic variation shapes protein networks mainly through non-transcriptional mechanisms.. PLoS biology. 9(9):e1001144. Abstract
Lessing D, Dial TO, Wei C, Payer B, Carrette LLG, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A et al..  2016.  A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.. Proceedings of the National Academy of Sciences. 113(50):14366-14371. Abstract
Chevillet JR, Park GJ, Bedalov A, Simon JA, Vasioukhin VI.  2008.  Identification and characterization of small-molecule inhibitors of hepsin.. Molecular cancer therapeutics. 7(10):3343-51. Abstract
Newcomb B, Bedalov A.  2009.  Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.. Methods in molecular biology (Clifton, N.J.). 548:145-60. Abstract
Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, Sahebol-Amri M, Koscik B, Ljuma L, Roy PJ, Bedalov A et al..  2008.  Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.. PLoS genetics. 4(2):e1000005. Abstract
Banfic H, Crljen V, Lukinovic-Skudar V, Dembitz V, Lalic H, Bedalov A, Visnjic D.  2015.  Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length.. Advances in biological regulation. Abstract
Banfic H, Bedalov A, York JD, Visnjic D.  2013.  Inositol pyrophosphates modulate S phase progression after pheromone-induced arrest in Saccharomyces cerevisiae.. The Journal of biological chemistry. 288(3):1717-25. Abstract
Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot P-P, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O.  2009.  Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.. Nature medicine. 15(2):206-10. Abstract
Kwan EX, Foss E, Kruglyak L, Bedalov A.  2011.  Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.. PLoS genetics. 7(8):e1002250. Abstract
Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A.  2013.  A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.. PLoS genetics. 9(3):e1003329. Abstract
Foss EJ, Radulovic D, Stirewalt DL, Radich J, Sala-Torra O, Pogosova-Agadjanyan EL, Hengel SM, Loeb KR, Deeg HJ, Meshinchi S et al..  2012.  Proteomic Classification of Acute Leukemias by Alignment-Based Quantitation of LC-MS/MS Data Sets.. Journal of proteome research. 11(10):5005-10. Abstract
Sripathy S, Leko V, Adrianse RL, Loe T, Foss EJ, Dalrymple E, Lao U, Gatbonton-Schwager T, Carter KT, Payer B et al..  2017.  Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression.. Proceedings of the National Academy of Sciences of the United States of America. Abstract
Foss EJ, Lao U, Dalrymple E, Adrianse RL, Loe T, Bedalov A.  2017.  SIR2 suppresses replication gaps and genome instability by balancing replication between repetitive and unique sequences.. Proceedings of the National Academy of Sciences of the United States of America. Abstract
Leko V, Varnum-Finney B, Li H, Gu Y, Flowers D, Nourigat C, Bernstein ID, Bedalov A.  2012.  SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.. Blood. 119(8):1856-1860. Abstract
Marshall GM, Liu P-Y, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W et al..  2011.  SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.. PLoS genetics. 7(6):e1002135. Abstract
Mahajan SS, Leko V, Simon JA, Bedalov A.  2011.  Sirtuin modulators.. Handbook of experimental pharmacology. (206):241-55. Abstract
Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK.  2013.  Sirtuins in yeast: phenotypes and tools.. Methods in molecular biology (Clifton, N.J.). 1077:11-37. Abstract
Wang J, Wegener JE, Huang T-W, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J et al..  2015.  Wild-type microglia do not reverse pathology in mouse models of Rett syndrome.. Nature. 521(7552):E1-4.