Center-Authored Papers

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Virus Replication
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H et al..  2015.  Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.. Nature. 517(7534):381-5. Abstract
Virus Latency
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H et al..  2015.  Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.. Nature. 517(7534):381-5. Abstract
Virus Diseases
Rongvaux A, Jackson R, Harman CCD, Li T, West PA, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan C-Y et al..  2014.  Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.. Cell. 159(7):1563-77. Abstract
Virulence
Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, Galán JE.  2010.  A mouse model for the human pathogen Salmonella typhi.. Cell host & microbe. 8(4):369-76. Abstract
Viral Load
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H et al..  2015.  Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.. Nature. 517(7534):381-5. Abstract
Vaccines
Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG et al..  2012.  NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.. Nature. 484(7395):510-3. Abstract
Vaccine and Infectious Disease Division
Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG.  2012.  Interleukin 23 Production by Intestinal CD103(+)CD11b(+) Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense.. Immunity. 36(2):276-87. Abstract
Up-Regulation
Andris F, Denanglaire S, Baus E, Rongvaux A, Steuve J, Flavell RA, Leo O.  2011.  Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.. Journal of immunology (Baltimore, Md. : 1950). 186(4):2245-53. Abstract
Typhoid Fever
Song J, Willinger T, Rongvaux A, Eynon EE, Stevens S, Manz MG, Flavell RA, Galán JE.  2010.  A mouse model for the human pathogen Salmonella typhi.. Cell host & microbe. 8(4):369-76. Abstract
Tropomyosin
Ye J, Llorian M, Cardona M, Rongvaux A, Moubarak RS, Comella JX, Bassel-Duby R, Flavell RA, Olson EN, Smith CWJ et al..  2013.  A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart.. Journal of cell science. 126(Pt 7):1682-91. Abstract
Transplantation, Heterologous
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S et al..  2011.  Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2378-83. Abstract
Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.  2013.  Human hemato-lymphoid system mice: current use and future potential for medicine.. Annual review of immunology. 31:635-74. Abstract
Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG et al..  2011.  Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung.. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2390-5. Abstract
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka KA et al..  2014.  Development and function of human innate immune cells in a humanized mouse model.. Nature biotechnology. 32(4):364-72. Abstract
Transplantation Chimera
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S et al..  2011.  Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2378-83. Abstract
Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG et al..  2011.  Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung.. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2390-5. Abstract
Translational Medical Research
Willinger T, Rongvaux A, Strowig T, Manz MG, Flavell RA.  2011.  Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement.. Trends in immunology. 32(7):321-7. Abstract
Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.  2013.  Human hemato-lymphoid system mice: current use and future potential for medicine.. Annual review of immunology. 31:635-74. Abstract
Transgenes
Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA.  2011.  Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13218-23. Abstract
Thrombopoietin
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S et al..  2011.  Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 108(6):2378-83. Abstract
Th17 Cells
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM et al..  2011.  Control of TH17 cells occurs in the small intestine.. Nature. 475(7357):514-8. Abstract
T-Lymphocytes, Helper-Inducer
Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG et al..  2012.  NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.. Nature. 484(7395):510-3. Abstract
T-Lymphocytes, Cytotoxic
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H et al..  2015.  Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.. Nature. 517(7534):381-5. Abstract
T-Lymphocytes
Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG et al..  2012.  NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.. Nature. 484(7395):510-3. Abstract
Stress, Physiological
Andris F, Denanglaire S, Baus E, Rongvaux A, Steuve J, Flavell RA, Leo O.  2011.  Metabolic stress boosts humoral responses in vivo independently of inflammasome and inflammatory reaction.. Journal of immunology (Baltimore, Md. : 1950). 186(4):2245-53. Abstract