Center-Authored Papers

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Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem H-P, Miller DG, Trobridge GD.  2015.  VISA - Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.. BMC bioinformatics. 16:212. Abstract
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Thakar MS, Zhang X-B, Beard BC, Sale GE, Santos EB, Peterson L, Kiem H-P, Sandmaier BM.  2009.  Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia model.. Experimental hematology. 37(10):1157-66. Abstract
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Trobridge GD, Beard BC, Wu RA, Ironside C, Malik P, Kiem H-P.  2012.  Stem cell selection in vivo using foamy vectors cures canine pyruvate kinase deficiency.. PloS one. 7(9):e45173. Abstract
Enssle J, Trobridge GD, Keyser KA, Ironside C, Beard BC, Kiem H-P.  2010.  Stable marking and transgene expression without progression to monoclonality in canine long-term hematopoietic repopulating cells transduced with lentiviral vectors.. Human gene therapy. 21(4):397-403. Abstract
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Kiem H-P, Ironside C, Beard BC, Trobridge GD.  2010.  A retroviral vector common integration site between leupaxin and zinc finger protein 91 (ZFP91) observed in baboon hematopoietic repopulating cells.. Experimental hematology. 38(9):819-22,822.e1-3. Abstract
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Trobridge GD, Wu RA, Beard BC, Chiu SY, Muñoz NM, von Laer D, Rossi JJ, Kiem H-P.  2009.  Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection.. PloS one. 4(11):e7693. Abstract
Berger C, Berger M, Beard BC, Kiem H-P, Gooley TA, Riddell SR.  2013.  Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques.. PloS one. 8(2):e56268. Abstract
Younan PM, Polacino P, Kowalski JP, Peterson CW, Maurice NJ, Williams NP, Ho O, Trobridge GD, von Laer D, Prlic M et al..  2013.  Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model.. Blood. Abstract
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Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem H-P.  2012.  Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.. Nucleic acids research. 40(2) Abstract
Watts KL, Beard BC, Wood BL, Trobridge GD, Humphries KR, Adams AB, Nelson V, Kiem H-P.  2014.  No Evidence of Clonal Dominance after Transplant of HOXB4-Expanded Cord Blood Cells in a Nonhuman Primate Model.. Experimental hematology. Abstract
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Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz J, Adair JE, Kiem H-P.  2018.  Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at ten-fold lower cell doses.. The journal of gene medicine. :e3050. Abstract
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Okazuka K, Beard BC, Emery DW, Schwarzwaelder K, Spector MR, Sale GE, von Kalle C, Kiem H-P, Blau AC.  2011.  Long-term regulation of genetically modified primary hematopoietic cells in dogs.. Molecular therapy : the journal of the American Society of Gene Therapy. 19(7):1287-94. Abstract
Beard BC, Sud R, Keyser KA, Ironside C, Neff T, Gerull S, Trobridge GD, Kiem H-P.  2009.  Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients.. Blood. 113(21):5094-103. Abstract
Trobridge GD, Horn PA, Beard BC, Kiem H-P.  2012.  Large animal models for foamy virus vector gene therapy.. Viruses. 4(12):3572-88. Abstract
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Burtner CR, Beard BC, Kennedy DR, Wohlfahrt ME, Adair JE, Trobridge GD, Scharenberg AM, Torgerson TR, Rawlings DJ, Felsburg PJ et al..  2014.  Intravenous injection of a foamy virus vector to correct canine SCID-X1.. Blood. 123(23):3578-84. Abstract
Piasecki JC, Beagles K, Beard BC, Riddell SR, Kiem H-P.  2008.  Induction of transgene-specific cytotoxic T lymphocyte responses after transplantation of gene-modified CD34+ cells despite nonablative immunosuppressive conditioning.. Human gene therapy. 19(1):103-7. Abstract
Gori JL, Beard BC, Williams NP, Ironside C, Swanson D, McIvor SR, Kiem HP.  2013.  In vivo protection of activated Tyr22-DHFR gene-modified canine T lymphocytes from methotrexate.. The journal of gene medicine. 15(6-7):233-41. Abstract
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Beard BC, Adair JE, Trobridge GD, Kiem H-P.  2014.  High-throughput genomic mapping of vector integration sites in gene therapy studies.. Methods in molecular biology (Clifton, N.J.). 1185:321-44. Abstract
Zhang X-B, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, Humphries KR, Kiem H-P.  2008.  High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector.. The Journal of clinical investigation. 118(4):1502-10. Abstract
Watts KL, Nelson V, Wood BL, Trobridge GD, Beard BC, Humphries KR, Kiem H-P.  2012.  Hematopoietic stem cell expansion facilitates multilineage engraftment in a nonhuman primate cord blood transplantation model.. Experimental hematology. 40(3):187-196. Abstract
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Adair JE, Johnston SK, Mrugala MM, Beard BC, Guyman LA, Baldock AL, Bridge CA, Hawkins-Daarud A, Gori JL, Born DE et al..  2014.  Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients.. The Journal of clinical investigation. 124(9):4082-92. Abstract
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Adair JE, Beard BC, Trobridge GD, Neff T, Rockhill JK, Silbergeld DL, Mrugala MM, Kiem H-P.  2012.  Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy.. Science translational medicine. 4(133):133ra57. Abstract
Trobridge GD, Beard BC, Gooch C, Wohlfahrt M, Olsen P, Fletcher J, Malik P, Kiem H-P.  2008.  Efficient transduction of pigtailed macaque hematopoietic repopulating cells with HIV-based lentiviral vectors.. Blood. 111(12):5537-43. Abstract
Gori JL, Chandrasekaran D, Kowalski JP, Adair JE, Beard BC, D'Souza SL, Kiem H-P.  2012.  Efficient generation, purification, and expansion of CD34+ hematopoietic progenitor cells from nonhuman primate induced pluripotent stem cells.. Blood. Abstract
Beard BC, Trobridge GD, Ironside C, McCune JS, Adair JE, Kiem H-P.  2010.  Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates.. The Journal of clinical investigation. 120(7):2345-54. Abstract