Center-Authored Papers

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Zheng H-F, Forgetta V, Hsu Y-H, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C et al..  2015.  Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.. Nature. 526(7571):112-7. Abstract
Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang Z-Z, Bizon C, Lange EM, Smith JD, Turner EH et al..  2014.  Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.. American journal of human genetics. 94(2):233-45. Abstract
Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen M-H, Auer PL, Floyd JS, Huang J et al..  2016.  Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.. American journal of human genetics. 99(2):481-8. Abstract
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Keller MF, Reiner AP, Okada Y, van Rooij FJA, Johnson AD, Chen M-H, Smith AV, Morris AP, Tanaka T, Ferrucci L et al..  2014.  Trans-ethnic Meta-analysis of White Blood Cell Phenotypes.. Human molecular genetics. 23(25):6944-60. Abstract
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Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C, Gorski M, Lyytikäinen L-P et al..  2016.  SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.. Journal of the American Society of Nephrology : JASN. Abstract
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Yu B, Pulit SL, Hwang S-J, Brody JA, Amin N, Auer PL, Bis JC, Boerwinkle E, Burke GL, Chakravarti A et al..  2015.  Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.. Circulation. Cardiovascular genetics. Abstract
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC et al..  2017.  Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.. Nature genetics. Abstract
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE, Altmaier E, He C et al..  2015.  Rare coding variants and X-linked loci associated with age at menarche.. Nature communications. 6:7756. Abstract
Huffman JE, de Vries PS, Morrison AC, Sabater-Lleal M, Kacprowski T, Auer PL, Brody JA, Chasman DI, Chen M-H, Guo X et al..  2015.  Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF.. Blood. 126(11):e19-e29. Abstract
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Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J et al..  2016.  A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.. Nature communications. 7:13357. Abstract
Ibrahim-Verbaas CA, Fornage M, Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M, Nalls M, Fontes JD, O'Donnell CJ et al..  2014.  Predicting Stroke Through Genetic Risk Functions: The CHARGE Risk Score Project.. Stroke; a journal of cerebral circulation. 45(2):403-12. Abstract
Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD et al..  2014.  Pleiotropic genes for metabolic syndrome and inflammation.. Molecular genetics and metabolism. Abstract
Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C et al..  2016.  PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.. The lancet. Diabetes & endocrinology. Abstract
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Lubitz SA, Lunetta KL, Lin H, Arking DE, Trompet S, Li G, Krijthe BP, Chasman DI, Barnard J, Kleber ME et al..  2014.  Novel Genetic Markers Associate with Atrial Fibrillation Risk in Europeans and Japanese.. Journal of the American College of Cardiology. Abstract
Jensen RA, Sim X, Smith AV, Li X, Jakobsdóttir J, Cheng C-Y, Brody JA, Cotch MF, McKnight B, Klein R et al..  2016.  Novel Genetic Loci Associated With Retinal Microvascular Diameter.. Circulation. Cardiovascular genetics. 9(1):45-54. Abstract
Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu AY, Trompet S, Lopez LM, Fornage M, Teumer A et al..  2014.  No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.. PloS one. 9(12):e111156. Abstract
Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T et al..  2016.  New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.. Nature communications. 7:10495. Abstract
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE et al..  2015.  New genetic loci link adipose and insulin biology to body fat distribution.. Nature. 518(7538):187-96. Abstract
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Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S et al..  2013.  Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.. Circulation. 128(12):1310-24. Abstract
de Vries PS, Chasman DI, Sabater-Lleal M, Chen M-H, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V et al..  2016.  A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.. Human molecular genetics. 25(2):358-70. Abstract
Joubert BR, den Dekker HT, Felix JF, Bohlin J, Ligthart S, Beckett E, Tiemeier H, van Meurs JB, Uitterlinden AG, Hofman A et al..  2016.  Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns.. Nature communications. 7:10577. Abstract
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Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B et al..  2015.  Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair--Editorial Comment. Obstetrical & Gynecological Survey. 70(12):758-762.
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B et al..  2015.  Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.. Nature genetics. 47(11):1294-1303. Abstract
Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA, Hill DW, Kacprowski T, Li J, Lyytikäinen L-P et al..  2016.  Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.. American journal of human genetics. Abstract
Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM et al..  2017.  Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.. Nature genetics. 49(6):946-952. Abstract