Center-Authored Papers

Filters: Author is Clurman, Bruce E  [Clear All Filters]
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2008
Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE.  2008.  Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase.. The Journal of cell biology. 181(6):913-20. Abstract
Chi Y, Welcker M, Hizli AA, Posakony JJ, Aebersold R, Clurman BE.  2008.  Identification of CDK2 substrates in human cell lysates.. Genome biology. 9(10):R149. Abstract
Welcker M, Clurman BE.  2008.  FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.. Nature reviews. Cancer. 8(2):83-93. Abstract
Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE.  2008.  Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.. Genes & development. 22(12):1677-89. Abstract
2011
Kuppers DA, Hwang HC, Jackson AL, Linsley PS, Clurman BE, Fero ML.  2011.  Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.. PloS one. 6(3):e14758. Abstract
Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC.  2011.  Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis.. Molecular and cellular biology. 31(18):3885-95. Abstract
Welcker M, Larimore EA, Frappier L, Clurman BE.  2011.  Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.. Molecular and cellular biology. 31(6):1214-24. Abstract
2012
Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI et al..  2012.  Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer.. Molecular and cellular biology. 32(11):2160-7. Abstract
2013
Pierce NW, Lee EJ, Liu X, Sweredoski MJ, Graham RLJ, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S et al..  2013.  Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.. Cell. 153(1):206-15. Abstract
Hughes BT, Sidorova J, Swanger J, Monnat RJ, Clurman BE.  2013.  Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.. Proceedings of the National Academy of Sciences of the United States of America. 110(22):8954-9. Abstract
Hizli AA, Chi Y, Swanger J, Carter JH, Liao Y, Welcker M, Ryazanov AG, Clurman BE.  2013.  Phosphorylation of Eukaryotic Elongation Factor 2 (eEF2) by Cyclin A-Cyclin-Dependent Kinase 2 Regulates Its Inhibition by eEF2 Kinase.. Molecular and cellular biology. 33(3):596-604. Abstract
Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim JE, Ericsson J, Zheng N, Clurman BE.  2013.  Fbw7 dimerization determines the specificity and robustness of substrate degradation.. Genes & development. 27(23):2531-6. Abstract
Sancho R, Blake SM, Tendeng C, Clurman BE, Lewis J, Behrens A.  2013.  Fbw7 repression by hes5 creates a feedback loop that modulates notch-mediated intestinal and neural stem cell fate decisions.. PLoS biology. 11(6):e1001586. Abstract
2014
Welcker M, Clurman BE.  2014.  Oncoprotein ubiquitylation: dimers, degrons, and degradation.. Cell cycle (Georgetown, Tex.). 13(12):1829-30.
Amino Acid Motifs
Welcker M, Larimore EA, Swanger J, Bengoechea-Alonso MT, Grim JE, Ericsson J, Zheng N, Clurman BE.  2013.  Fbw7 dimerization determines the specificity and robustness of substrate degradation.. Genes & development. 27(23):2531-6. Abstract
Animal
Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC.  2011.  Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis.. Molecular and cellular biology. 31(18):3885-95. Abstract
Animals
Welcker M, Clurman BE.  2008.  FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.. Nature reviews. Cancer. 8(2):83-93. Abstract
Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE.  2008.  Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.. Genes & development. 22(12):1677-89. Abstract
Hwang HC, Martins CP, Bronkhorst Y, Randel E, Berns A, Fero M, Clurman BE.  2002.  Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.. Proceedings of the National Academy of Sciences of the United States of America. 99(17):11293-8. Abstract
Garrett-Engele CM, Tasch MA, Hwang HC, Fero ML, Perlmutter RM, Clurman BE, Roberts JM.  2007.  A mechanism misregulating p27 in tumors discovered in a functional genomic screen.. PLoS genetics. 3(12):e219. Abstract
Sengupta T, Abraham G, Xu Y, Clurman BE, Minella AC.  2011.  Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis.. Molecular and cellular biology. 31(18):3885-95. Abstract
Kuppers DA, Hwang HC, Jackson AL, Linsley PS, Clurman BE, Fero ML.  2011.  Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.. PloS one. 6(3):e14758. Abstract
Apr 2012
Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI et al..  2012.  Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer.. Molecular and cellular biology. 32(11):2160-7. Abstract
April 2012
Grim JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI et al..  2012.  Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer.. Molecular and cellular biology. 32(11):2160-7. Abstract
April 2013
Pierce NW, Lee EJ, Liu X, Sweredoski MJ, Graham RLJ, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S et al..  2013.  Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.. Cell. 153(1):206-15. Abstract