Yorkie and Scalloped: partners in growth activation.

Publication Type:

Journal Article

Source:

Developmental cell, Volume 14, Issue 3, p.315-6 (2008)

Keywords:

2008, Animals, Basic Sciences Division, DROSOPHILA, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Models, Biological, Nuclear Proteins, Protein-Serine-Threonine Kinases, Signal Transduction, Trans-Activators, TRANSCRIPTION FACTORS

Abstract:

The Hippo (Hpo) signaling pathway limits organ growth in organisms from Drosophila to mammals by suppressing the activity of the transcriptional coactivator Yorkie (Yki)/YAP. The TEAD/TEF factor Scalloped (Sd) has been identified as the first known transcription factor to partner with Yki as a downstream target of Hpo signaling.