Waveform analysis-guided treatment versus a standard shock-first protocol for the treatment of out-of-hospital cardiac arrest presenting in ventricular fibrillation: results of an international randomized, controlled trial.

Publication Type:

Journal Article


Circulation, Volume 128, Issue 9, p.995-1002 (2013)


2013, Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Cardiopulmonary Resuscitation, Defibrillators, Disease Management, Double-Blind Method, Female, Humans, International Cooperation, Male, Middle Aged, October 2013, Out-of-Hospital Cardiac Arrest, Outcome Assessment (Health Care), Prospective Studies, Public Health Sciences Division, Survival Rate, Treatment Outcome, Ventricular Fibrillation, Young Adult


Ventricular fibrillation (VF) waveform properties have been shown to predict defibrillation success and outcomes among patients treated with immediate defibrillation. We postulated that a waveform analysis algorithm could be used to identify VF unlikely to respond to immediate defibrillation, allowing selective initial treatment with cardiopulmonary resuscitation in an effort to improve overall survival.