In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.

Publication Type:

Journal Article

Source:

PloS one, Volume 5, Issue 2, p.e9310 (2010)

Keywords:

2010, Adenine, Anti-HIV Agents, Caco-2 Cells, Cell Survival, Cells, Cultured, Center-Authored Paper, Cervix Uteri, Colon, Drug Evaluation, Preclinical, Female, Gels, HIV-1, Humans, Leukocytes, Mononuclear, Phosphonic Acids, Rectum, Tissue Culture Techniques, Vaccine and Infectious Disease Division

Abstract:

Tenofovir gel has entered into clinical trials for use as a topical microbicide to prevent HIV-1 infection but has no published data regarding pre-clinical testing using in vitro and ex vivo models. To validate our findings with on-going clinical trial results, we evaluated topical tenofovir gel for safety and efficacy. We also modeled systemic application of tenofovir for efficacy.