Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial.

Publication Type:

Journal Article


PloS one, Volume 6, Issue 3, p.e16986 (2011)


2011, Adult, Bayes Theorem, Demography, env Gene Products, Human Immunodeficiency Virus, Female, gag Gene Products, Human Immunodeficiency Virus, Genetic Linkage, HIV Seropositivity, HIV-1, Humans, Male, Phylogeny, Sequence Analysis, DNA, Sexual Partners, Vaccine and Infectious Disease Division


Characterization of viruses in HIV-1 transmission pairs will help identify biological determinants of infectiousness and evaluate candidate interventions to reduce transmission. Although HIV-1 sequencing is frequently used to substantiate linkage between newly HIV-1 infected individuals and their sexual partners in epidemiologic and forensic studies, viral sequencing is seldom applied in HIV-1 prevention trials. The Partners in Prevention HSV/HIV Transmission Study ( #NCT00194519) was a prospective randomized placebo-controlled trial that enrolled serodiscordant heterosexual couples to determine the efficacy of genital herpes suppression in reducing HIV-1 transmission; as part of the study analysis, HIV-1 sequences were examined for genetic linkage between seroconverters and their enrolled partners.