Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial.

Publication Type:

Journal Article

Source:

PloS one, Volume 6, Issue 3, p.e16986 (2011)

Keywords:

2011, Adult, Bayes Theorem, Demography, env Gene Products, Human Immunodeficiency Virus, Female, gag Gene Products, Human Immunodeficiency Virus, Genetic Linkage, HIV Seropositivity, HIV-1, Humans, Male, Phylogeny, Sequence Analysis, DNA, Sexual Partners, Vaccine and Infectious Disease Division

Abstract:

Characterization of viruses in HIV-1 transmission pairs will help identify biological determinants of infectiousness and evaluate candidate interventions to reduce transmission. Although HIV-1 sequencing is frequently used to substantiate linkage between newly HIV-1 infected individuals and their sexual partners in epidemiologic and forensic studies, viral sequencing is seldom applied in HIV-1 prevention trials. The Partners in Prevention HSV/HIV Transmission Study (ClinicalTrials.gov #NCT00194519) was a prospective randomized placebo-controlled trial that enrolled serodiscordant heterosexual couples to determine the efficacy of genital herpes suppression in reducing HIV-1 transmission; as part of the study analysis, HIV-1 sequences were examined for genetic linkage between seroconverters and their enrolled partners.