VEGF induces differentiation of functional endothelium from human embryonic stem cells: implications for tissue engineering.

Publication Type:

Journal Article


Arteriosclerosis, thrombosis, and vascular biology, Volume 30, Issue 1, p.80-9 (2010)


2010, Animals, Biological Markers, Cell Culture Techniques, Cell Differentiation, Center-Authored Paper, Clinical Research Division, Collagen, Dose-Response Relationship, Drug, Drug Combinations, Embryonic Stem Cells, Endothelial Cells, Humans, Intercellular Adhesion Molecule-1, Laminin, Male, Myocardial Reperfusion Injury, Neovascularization, Physiologic, Proteoglycans, Public Health Sciences Division, Rats, Rats, Nude, Tissue Engineering, U937 Cells, Umbilical Veins, Vascular Cell Adhesion Molecule-1, Vascular Endothelial Growth Factor A


Human embryonic stem cells (hESCs) offer a sustainable source of endothelial cells for therapeutic vascularization and tissue engineering, but current techniques for generating these cells remain inefficient. We endeavored to induce and isolate functional endothelial cells from differentiating hESCs.