Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 17, Issue 5, p.1144-54 (2008)

Keywords:

2008, Adenoma, Aged, Case-Control Studies, Center-Authored Paper, Colorectal Neoplasms, Genetic Variation, Genotype, Glutathione Peroxidase, Haplotypes, Humans, Logistic Models, Middle Aged, Polymorphism, Single Nucleotide, Public Health Sciences Division, Questionnaires, Research Trials Office Core Facility - Biostatistics Service, RISK, Selenium, Selenoprotein P, Shared Resources, Thioredoxin Reductase 1

Abstract:

Epidemiologic and animal studies provide evidence for a chemopreventive effect of selenium on colorectal cancer, which may be mediated by the antioxidative and anti-inflammatory properties of selenoenzymes. We therefore investigated whether genetic variants in selenoenzymes abundantly expressed in the colon are associated with advanced colorectal adenoma, a cancer precursor.