Variation in the FGFR2 gene and the effect of a low-fat dietary pattern on invasive breast cancer.

Publication Type:

Journal Article


Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 19, Issue 1, p.74-9 (2010)


2010, Adult, Aged, Breast Neoplasms, Center-Authored Paper, diet, Dietary Fats, Female, Food Habits, Genotype, Humans, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Postmenopause, Public Health Sciences Division, Receptor, Fibroblast Growth Factor, Type 2, Shared Resources, Specimen Processing Core Facility


The Women's Health Initiative dietary modification (DM) trial provided suggestive evidence of a benefit of a low-fat dietary pattern on breast cancer risk, with stronger evidence among women whose baseline diet was high in fat. Single nucleotide polymorphisms (SNP) in the FGFR2 gene relate strongly to breast cancer risk and could influence intervention effects.