Valganciclovir for suppression of human herpesvirus-8 replication: a randomized, double-blind, placebo-controlled, crossover trial.

Publication Type:

Journal Article


The Journal of infectious diseases, Volume 198, Issue 1, p.23-30 (2008)


2008, Adult, Aged, Antiviral Agents, Cross-Over Studies, Double-Blind Method, Ganciclovir, Herpesvirus 8, Human, HIV Infections, Humans, Male, Middle Aged, Oropharynx, Patient Compliance, Sarcoma, Kaposi, Vaccine and Infectious Disease Institute, Virus Replication, Virus Shedding


Human herpesvirus-8 (HHV-8) replication is critical in the induction and maintenance of Kaposi sarcoma, primary effusion lymphoma, and some cases of Castleman disease. In vitro and observational studies suggest that ganciclovir inhibits HHV-8 replication, but no randomized clinical trials have been conducted.