Vaginal Langerhans cells non-productively transporting HIV-1 mediate infection of T cells.

Publication Type:

Journal Article

Source:

Journal of virology, Volume 85, Issue 24, p.13443-7 (2011)

Keywords:

2011, CD4-Positive T-Lymphocytes, Cell Movement, Center-Authored Paper, Female, HIV Infection, HIV-1, Humans, Langerhans Cells, October 2011, Vaccine and Infectious Disease Division, Vagina

Abstract:

Although implied by other models, proof has been lacking that Langerhans cells (LCs) in the human vagina participate in dissemination of infectious HIV-1. Here, we show that LCs migrate from HIV-1 exposed vaginal epithelia and pass infectious virus to CD4(+) T cells without being productively infected themselves, and point to a pathway that might enable HIV-1 to avoid degradation in vaginal LCs. Transport by migratory LCs to local lymphatics in a non-productive but infectious form may aid HIV-1 to evade topical microbicides that target its intracellular productive life cycle.