Vaccine Induced Epitope Specific Antibodies to SIVmac239 Envelope Are Distinct from Those Induced to the HIV-1 Envelope in Non-Human Primates.

Publication Type:

Journal Article

Source:

Journal of virology (2015)

Abstract:

To evaluate antibody specificities induced by SIV versus HIV-1 envelope antigens in non-human primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that overall HIV-1 Env IgG responses were dominated by V3, notably with the exception of responses to the RV144 vaccine strain immunogen (A244 Env) that was dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of vaccine regimens.