Using plasma viral load to guide antiretroviral therapy initiation to prevent HIV-1 transmission.

Publication Type:

Journal Article


PloS one, Volume 7, Issue 11, p.e51192 (2012)


2012, Center-Authored Paper, Clinical Research Division, January 2013, Public Health Sciences Division, Vaccine and Infectious Disease Division


Current WHO guidelines recommend antiretroviral therapy (ART) initiation at CD4 counts ≤350 cells/µL. Increasing this threshold has been proposed, with a primary goal of reducing HIV-1 infectiousness. Because the quantity of HIV-1 in plasma is the primary predictor of HIV-1 transmission, consideration of plasma viral load in ART initiation guidelines is warranted.