USF1 gene variants, cardiovascular risk, and mortality in European Americans: analysis of two US cohort studies.

Publication Type:

Journal Article

Source:

Arteriosclerosis, thrombosis, and vascular biology, Volume 27, Issue 12, p.2736-42 (2007)

Keywords:

Adult, Age Factors, Aged, Aged, 80 and over, Aging, Blood Glucose, C-Reactive Protein, Calcium, Cardiovascular Diseases, Carotid Artery, Common, Cohort Studies, Coronary Artery Disease, Coronary Vessels, European Continental Ancestry Group, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Hyperlipidemia, Familial Combined, Insulin, Interleukin-6, LINKAGE DISEQUILIBRIUM, lipids, Male, Odds Ratio, PHENOTYPE, Polymorphism, Single Nucleotide, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, United States, Upstream Stimulatory Factors

Abstract:

A common haplotype of the upstream transcription factor 1 gene (USF1) has been associated with decreased susceptibility to familial combined hyperlipidemia (FCHL) and, paradoxically, with increased risk of cardiovascular disease (CVD) and all-cause mortality.