Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage.

Publication Type:

Journal Article

Source:

Gastroenterology, Volume 135, Issue 2, p.410-8 (2008)

Keywords:

2008, Adolescent, Adult, Age Distribution, Age Factors, Aged, Aging, Center-Authored Paper, Child, Child, Preschool, Colitis, Ulcerative, Colon, Colorectal Neoplasms, Cross-Sectional Studies, DNA Damage, Female, Fluorescent Antibody Technique, Histones, Humans, In Situ Hybridization, Fluorescence, Intestinal Mucosa, Leukocytes, Male, Middle Aged, PHOSPHORYLATION, Polymerase Chain Reaction, Public Health Sciences Division, Research Trials Office Core Facility - Biostatistics Service, Shared Resources, Specimen Processing Core Facility, Stromal Cells, Telomere, Up-Regulation

Abstract:

Telomere shortening is implicated in cancer and aging and might link these 2 biologic events. We explored this hypothesis in ulcerative colitis (UC), a chronic inflammatory disease that predisposes to colorectal cancer and in which shorter telomeres have been associated with chromosomal instability and tumor progression.