Tumor growth rate is an early indicator of antitumor drug activity in phase I clinical trials.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 20, Issue 1, p.246-52 (2014)

Keywords:

2014, February 2014, Public Health Sciences Division

Abstract:

Response Evaluation Criteria in Solid Tumors (RECIST) evaluation does not take into account the pretreatment tumor kinetics and may provide incomplete information about experimental drug activity. Tumor growth rate (TGR) allows for a dynamic and quantitative assessment of the tumor kinetics. How TGR varies along the introduction of experimental therapeutics and is associated with outcome in phase I patients remains unknown.