Treatments and outcomes for end-stage renal disease following Wilms tumor.

Publication Type:

Journal Article

Authors:

Grigoriev, Yevgeny; Lange, Jane; Peterson, Susan M; Takashima, Janice R; Ritchey, Michael L; Ko, Dicken; Feusner, James H; Shamberger, Robert C; Green, Daniel M; Breslow, Norman E

Source:

Pediatric nephrology (Berlin, Germany) (2012)

Keywords:

2012, April 2012, Public Health Sciences Division

Abstract:

BACKGROUND: Little is known about treatment outcomes for children who have end-stage renal disease (ESRD) after treatment for Wilms tumor (WT). METHODS: Time-to-transplant, graft failure, and survival outcomes were examined for 173 children enrolled on the National Wilms Tumor Study who developed ESRD. RESULTS: Fifty-five patients whose ESRD resulted from progressive bilateral WT (PBWT) experienced high early mortality from WT that limited their opportunity for transplant (47% at 5 years) and survival (44% at 10 years) in comparison to population controls. The 118 patients whose ESRD was due to other causes (termed "chronic kidney disease"), many of whom had WT-associated congenital anomalies, had transplant (77% at 5 years) and survival (73% at 10 years) outcomes no worse than those for population controls. Graft failure following transplant was comparable for the two groups. Minority children had twice the median time to transplant as non-Hispanic whites and twice the mortality rates, also reflecting population trends. CONCLUSIONS: In view of the continuing high mortality in patients with ESRD, and the dramatic improvement in outlook following kidney transplantation, re-evaluation of current guidelines for a 2-year delay in transplant following WT treatment may be warranted.