Treatment of lymphoma with adoptively transferred T cells.

Publication Type:

Journal Article

Source:

Expert opinion on biological therapy, Volume 9, Issue 11, p.1407-25 (2009)

Keywords:

2009, Adoptive Transfer, Cell Processing Core Facility, Center-Authored Paper, Clinical Research Division, Cytokine Analysis Core Facility, Flow Cytometry Core Facility, Genomics Core Facility, Herpesvirus 4, Human, Humans, Lymphoma, Receptors, Antigen, T-Cell, Shared Resources, Specimen Processing Core Facility, Translational Bioimaging Center Core Facility

Abstract:

Chemotherapy-resistant lymphomas can be cured with allogeneic hematopoietic cell transplantation, demonstrating the susceptibility of these tumors to T cell mediated immune responses. However, high rates of transplant-related morbidity and mortality limit this approach. Efforts have, therefore, been made to develop alternative T cell based therapies, and there is growing evidence that adoptive therapy with T cells targeted to lymphoma-associated antigens may be a safe and effective new method for treating this group of diseases.