Treatment of children with acute promyelocytic leukemia: results of the first North American Intergroup trial INT0129.

Publication Type:

Journal Article

Source:

Pediatric blood & cancer, Volume 53, Issue 6, p.1005-10 (2009)

Keywords:

2009, Adolescent, Center-Authored Paper, Child, Child, Preschool, Clinical Research Division, Cytarabine, Daunorubicin, Female, Humans, Infant, Leukemia, Promyelocytic, Acute, Male, Remission Induction, Survival Analysis, Treatment Outcome, Tretinoin

Abstract:

This report focuses on the children enrolled on the first North American Intergroup study of APL (INT0129). This study was designed to compare the rates of CR, disease-free survival (DFS), overall survival (OS) and toxicity of therapy with all-trans-retinoic acid (ATRA) for remission induction and/or maintenance compared to conventional chemotherapy in patients with previously untreated APL.