Treating transcriptional addiction in small cell lung cancer.

Publication Type:

Journal Article


Cancer cell, Volume 26, Issue 6, p.783-4 (2014)


Animals, Antineoplastic Agents, Enzyme Inhibitors, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, TRANSCRIPTION FACTORS


Small cell lung cancer (SCLC) is a devastating tumor type with great therapeutic need. In this issue of Cancer Cell, Christensen and colleagues identify THZ1, a CDK7 inhibitor, as a potential therapy for SCLC. Using cells and mouse models, the authors show exquisite sensitivity of SCLC to transcriptional inhibition.