Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells.

Publication Type:

Journal Article

Source:

Genome biology, Volume 9, Issue 1, p.R19 (2008)

Keywords:

2008, Cell Death, Cell Differentiation, Cell Line, Cell Proliferation, Energy Metabolism, Gene Expression Regulation, Hepatocytes, Humans, immunity, liver, Protein Biosynthesis, Public Health Sciences Division, RNA, Messenger, Stem Cells

Abstract:

We investigated the molecular events associated with the differentiation of liver progenitor cells into functional and polarized hepatocytes, using human HepaRG cells that display potent hepatocytic differentiation-inducible properties and share some features with liver progenitor cells.