Towards an integrated proteomic and glycomic approach to finding cancer biomarkers.

Publication Type:

Journal Article

Source:

Genome medicine, Volume 1, Issue 6, p.57 (2009)

Keywords:

2009, Center-Authored Paper, Public Health Sciences Division

Abstract:

ABSTRACT : Advances in mass spectrometry have had a great impact on the field of proteomics. A major challenge of proteomic analysis has been the elucidation of glycan modifications of proteins in complex proteomes. Glycosylation is the most structurally elaborate and diverse type of protein post-translational modification and, because of this, proteomics and glycomics have largely developed independently. However, given that such a large proportion of proteins contain glycan modifications, and that these may be important for their function or may produce biologically relevant protein variation, a convergence of the fields of glycomics and proteomics would be highly desirable. Here we review the current status of glycoproteomic efforts, focusing on the identification of glycoproteins as cancer biomarkers.