Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases, Volume 197, Issue 2, p.253-61 (2008)

Keywords:

2008, Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Ethiopia, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Infant, Infant, Newborn, Leprosy, LINKAGE DISEQUILIBRIUM, Male, Microsatellite Repeats, Middle Aged, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Public Health Sciences Division, Toll-Like Receptor 2

Abstract:

Leprosy is characterized by a spectrum of clinical manifestations that depend on the type of immune response against the pathogen. Patients may undergo immunological changes known as "reactional states" (reversal reaction and erythema nodosum leprosum) that result in major clinical deterioration. The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy.