Timing of weight gain and breast cancer risk.

Publication Type:

Journal Article


Cancer, Volume 76, Issue 2, p.243-9 (1995)


Adult, Age Factors, Aged, Body Composition, Body Weight, Breast Neoplasms, CARCINOMA, Female, Humans, Menopause, Middle Aged, Multivariate Analysis, Risk Factors


Obesity and body-fat distribution have been associated with the incidence of breast and endometrial cancers. It may be critical to determine if the timing of weight gain during periods of hormonal change, such as menarche, pregnancy, or menopause, has different biologic effects, especially secondary to differences in the localization of body fat during these periods. The objective of the current study was to determine if excess weight in any particular decade of life or the timing of weight gain was more significant relative to breast cancer risk.