Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features.

Publication Type:

Journal Article


PloS one, Volume 3, Issue 4, p.e1890 (2008)


2008, 258, Barrett Esophagus, Cell Differentiation, DISEASE PROGRESSION, Disease-Free Survival, Endoscopy, Epigenesis, Genetic, Esophageal Neoplasms, Humans, METHYLATION, Precancerous Conditions, Reproducibility of Results, RISK, Risk Assessment, ROC Curve, Treatment Outcome


Barrett's esophagus predisposes to esophageal adenocarcinoma. However, the value of endoscopic surveillance in Barrett's esophagus has been debated because of the low incidence of esophageal adenocarcinoma in Barrett's esophagus. Moreover, high inter-observer and sampling-dependent variation in the histologic staging of dysplasia make clinical risk assessment problematic. In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency.