Temporal regulation of Dpp signaling output in the Drosophila wing.

Publication Type:

Journal Article


Developmental dynamics : an official publication of the American Association of Anatomists, Volume 243, Issue 6, p.818-32 (2014)


2014, Basic Sciences Division, Center-Authored Paper, Genomics Core Facility, July 2014


The Decapentaplegic (Dpp) signaling pathway is used in many developmental and homeostatic contexts, each time resulting in cellular responses particular to that biological niche. The flexibility of Dpp signaling is clearly evident in epithelial cells of the Drosophila wing imaginal disc. During larval stages of development, Dpp functions as a morphogen, patterning the wing developmental field and stimulating tissue growth. A short time later, however, as wing-epithelial cells exit the cell cycle and begin to differentiate, Dpp is a critical determinant of vein-cell fate. It is likely that the Dpp signaling pathway regulates different sets of target genes at these two developmental time points.