T-cell receptor sequencing reveals the clonal diversity and overlap of colonic effector and FOXP3+ T cells in ulcerative colitis.

Publication Type:

Journal Article

Source:

Inflammatory bowel diseases, Volume 21, Issue 1, p.19-30 (2015)

Abstract:

FOXP3 regulatory T cell prevent inflammation but are paradoxically increased in ulcerative colitis (UC). Local T-cell activation has been hypothesized to account for increased FOXP3 expression in colon lamina propria (LP) T cells.