A systematic search for SNPs/haplotypes associated with disease phenotypes using a haplotype-based stepwise procedure.

Publication Type:

Journal Article

Source:

BMC genetics, Volume 9, p.90 (2008)

Keywords:

2008, Algorithms, Alleles, Case-Control Studies, Clinical Research Division, Cohort Studies, Computer Simulation, Gene Frequency, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, LINKAGE DISEQUILIBRIUM, Logistic Models, Models, Statistical, PHENOTYPE, Polymorphism, Single Nucleotide, Public Health Sciences Division

Abstract:

Genotyping technologies enable us to genotype multiple Single Nucleotide Polymorphisms (SNPs) within selected genes/regions, providing data for haplotype association analysis. While haplotype-based association analysis is powerful for detecting untyped causal alleles in linkage-disequilibrium (LD) with neighboring SNPs/haplotypes, the inclusion of extraneous SNPs could reduce its power by increasing the number of haplotypes with each additional SNP.