Systematic evaluation of candidate blood markers for detecting ovarian cancer.

Publication Type:

Journal Article


PloS one, Volume 3, Issue 7, p.e2633 (2008)


2008, Female, Humans, Neoplasms, Glandular and Epithelial, Oligonucleotide Array Sequence Analysis, Ovarian Neoplasms, Public Health Sciences Division, Tumor Markers, Biological


Epithelial ovarian cancer is a significant cause of mortality both in the United States and worldwide, due largely to the high proportion of cases that present at a late stage, when survival is extremely poor. Early detection of epithelial ovarian cancer, and of the serous subtype in particular, is a promising strategy for saving lives. The low prevalence of ovarian cancer makes the development of an adequately sensitive and specific test based on blood markers very challenging. We evaluated the performance of a set of candidate blood markers and combinations of these markers in detecting serous ovarian cancer.