Survival Benefit of Early Infant Antiretroviral Therapy is Compromised when Diagnosis is Delayed.

Publication Type:

Journal Article

Source:

The Pediatric infectious disease journal, Volume 31, Issue 7, p.729-731 (2012)

Keywords:

2012, Center-Authored Paper, May 2012, Vaccine and Infectious Disease Division

Abstract:

Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by age 5 months. Twelve-month survival was 66.8% (95% confidence interval, 55.9%, 75.6%). WHO stage 3/4, underweight, wasting, microcephaly, low hemoglobin, pneumonia, and gastroenteritis predicted mortality. Early HIV-1 diagnosis with ART before symptomatic disease is critical for infant survival.