Sunlight, Polymorphisms of Vitamin D-related Genes and Risk of Breast Cancer.

Publication Type:

Journal Article

Source:

Anticancer research, Volume 33, Issue 2, p.543-51 (2013)

Keywords:

February 2013, Public Health Sciences Division

Abstract:

Background/Aim: Geographic gradients in breast cancer incidence and mortality suggest that vitamin D may reduce risk. The enzyme 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), which degrades the active form of vitamin D, and the vitamin D receptor (VDR) are both found in breast tissue. We investigated six polymorphisms in CYP24A1 and two in the VDR gene in association with breast cancer risk.