Successful Isolation of Infectious and High Titer Human Monocyte-Derived HIV-1 from Two Subjects with Discontinued Therapy.

Publication Type:

Journal Article

Source:

PloS one, Volume 8, Issue 5, p.e65071 (2013)

Keywords:

2013, June 2013, Public Health Sciences Division, Vaccine and Infectious Disease Division

Abstract:

HIV-1 DNA in blood monocytes is considered a viral source of various HIV-1 infected tissue macrophages, which is also known as "Trojan horse" hypothesis. However, whether these DNA can produce virions has been an open question for years, due to the inability of isolating high titer and infectious HIV-1 directly from monocytes.