Statin use and incident frailty in women aged 65 years or older: prospective findings from the Women's Health Initiative Observational Study.

Publication Type:

Journal Article


The journals of gerontology. Series A, Biological sciences and medical sciences, Volume 63, Issue 4, p.369-75 (2008)


2008, Aged, Aging, Anti-Inflammatory Agents, Center-Authored Paper, Drug Utilization, Fatigue, Female, Frail Elderly, Geriatric Assessment, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Motor Activity, Prevention Center Core Facility, Prospective Studies, Public Health Sciences Division, Shared Resources, Weight Loss, Women's Health


Inflammatory biomarkers have shown consistent associations with disability and frailty in older adults. Statin medications may reduce the incidence the frailty because of their anti-inflammatory effects. This study examines associations between current use, duration, and potency of statin medications and incident frailty in initially nonfrail women 65 years old or older.