Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 16, Issue 4, p.1331-9 (2010)

Keywords:

2010, Adult, Aged, Aged, 80 and over, Center-Authored Paper, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA Mismatch Repair, Epidemiology Core Facility, Female, Humans, Male, Middle Aged, Mutation, Public Health Sciences Division, Risk Assessment, Risk Factors, Shared Resources, Smoking, Specimen Processing Core Facility

Abstract:

Lynch syndrome family members with inherited germline mutations in DNA mismatch repair (MMR) genes have a high risk of colorectal cancer (CRC), and cases typically have tumors that exhibit a high level of microsatellite instability (MSI). There is some evidence that smoking is a risk factor for CRCs with high MSI; however, the association of smoking with CRC among those with Lynch syndrome is unknown.