Siderocalins: siderophore-binding proteins of the innate immune system.

Publication Type:

Journal Article


Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, Volume 22, Issue 4, p.557-64 (2009)


2009, Animals, Basic Sciences Division, Humans, Immunity, Innate, Lipocalins, Protein Binding, Protein Structure, Secondary, Protein Structure, Tertiary, Siderophores


Recent studies have revealed that the mammalian immune system directly interferes with siderophore-mediated iron acquisition through siderophore-binding proteins and that the association of certain siderophores, or siderophore modifications, with virulence is a direct response of pathogens to evade these defenses.