A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.

Publication Type:

Journal Article


Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 20, Issue 4, p.658-64 (2011)


2011, Aged, Aged, 80 and over, Americas, Case-Control Studies, Chromosomes, Human, Pair 15, Europe, Female, Genotype, Head and Neck Neoplasms, Humans, Male, Middle Aged, Public Health Sciences Division, Sex Factors, Smoking


Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35).