Sex hormone associations with breast cancer risk and the mediation of randomized trial postmenopausal hormone therapy effects.

Publication Type:

Journal Article


Breast cancer research : BCR, Volume 16, Issue 2, p.R30 (2014)


2014, April 2014, Public Health Sciences Division


Paradoxically, a breast cancer risk reduction with conjugated equine estrogens (CEE) and a risk elevation with CEE plus medroxyprogesterone acetate (CEE + MPA) were observed in the Women's Health Initiative (WHI) randomized controlled trials. The effects of hormone therapy on serum sex hormone levels, and on the association between baseline sex hormones and disease risk, may help explain these divergent breast cancer findings.