Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers.

Publication Type:

Journal Article


Environmental health perspectives, Volume 117, Issue 9, p.1402-8 (2009)


2009, Adolescent, Adult, Agriculture, Aryldialkylphosphatase, Butyrylcholinesterase, Center-Authored Paper, Cholinesterase Inhibitors, Female, Humans, Male, Middle Aged, Occupational Exposure, Public Health Sciences Division, Washington, Young Adult


Animal studies have demonstrated that low paraoxonase-1 (PON1) status (i.e., low catalytic efficiency and/or low plasma PON1 activity) is associated with neurotoxic effects after exposure to several organophosphate (OP) insecticides. However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals.