A sequential treatment approach to myoinvasive urothelial cancer: a phase II Southwest Oncology Group trial (S0219).

Publication Type:

Journal Article

Source:

The Journal of urology, Volume 181, Issue 6, p.2476-80; discussion 2480-1 (2009)

Keywords:

2009, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carboplatin, Carcinoma, Transitional Cell, Cystectomy, Deoxycytidine, Female, Humans, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Invasiveness, paclitaxel, Public Health Sciences Division, Urinary Bladder Neoplasms

Abstract:

We conducted a phase II trial of neoadjuvant paclitaxel, carboplatin and gemcitabine as well as transurethral resection of bladder tumor to evaluate the clinical T0 (cT0) rate with paclitaxel, carboplatin and gemcitabine, and to study cystoscopic surveillance or immediate cystectomy for patients with cT0 status following chemotherapy.